Melanoma metastases caught in the AKT
نویسندگان
چکیده
Dysregulated protein kinase B alpha (PKB/AKT1) signaling has been increasingly implicated in melanoma metastasis to distant organs, especially the brain. In a recent study, we expressed activated AKT1 in a non-metastatic melanoma model in vivo and discovered that AKT1 activation decreased tumor latency and elicited lung and brain metastases in this context.
منابع مشابه
Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases
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